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Feature

Benefit

Sensitive to endogenous receptors

Enables reliable and robust measurements of endogenous cellular receptor activity,， even low density receptors which may be undetectable with other functional assays.

Label free detection

Expensive tags,， dyes， or specialized reagents are not required. This reduces the resources required for assay development and eliminates the incidence of undesirable interactions with labels.

Universal platform for functional cell surface target assays

Single platform and assay methodology measures GPCRs,， TKRs,， adhesion molecules， and indirectly measures ligand-gated ion channels,， among other targets.

Measures all cell types

System measures disease and biologically relevant cell lines and primary cells,， including adherent and non-adherent cell types.

Measures all classes of compound efficacy

Comprehensive detection of agonists， antagonists,， partial and inverse agonists,， and allosteric modulators in a native setting in a single assay.

Information-rich kinetic response data

Reproducible and robust qualitative pathway-specific cell response profiles.

Probe complex receptor signaling， pathway diversity,， and identify the underlying mechanism of action (MOA) of lead compounds.

Streamlined assay development

Single-assay format for multiple receptor types regardless of signal coupling mechanism.

Reduces the resources spent on assay development,， such as time consuming and costly biological manipulation of cell lines and the optimization of labeling reagents.

Integrated， internal pipettor head

Simultaneous addition of ligand and/or compound while measuring the fast kinetic cellular responses,， delivers reproducible and robust response profiles,， with no loss of information.

Automation-friendly

Designed for easy robotic integration with small and large scale automation platforms.

Ease of use

The CellKey System is a fully integrated， flexible,， and intuitive platform.

Measurements

Assay type:

Homogeneous,， label-free， cell-based

Principles:

Impedance

Frequency range:

1 kHz-10 MHz

Mode:

Kinetic measurement: simultaneous compound addition and measurement across all wells

Data acquisition rate:

2 or 10 second update rate

Microplate Formats

Cell plate format:

96-well proprietary cell plate

Compound plate format:

96-well and 384-well compound plates and reservoirs

Deck positions:

One read (cell plate) position

Two compound plate positions

One tip loading position

Fluidics

Pipettor format:

One 96 well pipettor head,， simultaneous transfer

Pipettor range:

0.5-200 μL

Pipetting increments:

0.1 μL

Dispense speed:

Adjustable

Pipettor height:

Adjustable

Additional standard features:

Compound mix capability

Throughput

Assay development:

4 plates/hour (15-minute read time)

High-throughput:

8 plates/hour or better (5-minute read time,， plus automation)

Temperature Range

Analysis range:

Ambient +5° to 37°C (below 20°C， ambient +6°)

Ambient range:

15-30^oC

Physical Characteristics

Benchtop

Yes

Instrument weight:

128 kg/282 lbs

Instrument dimensions (in):

28 (H) x 33 (W) x 23 (D)

Instrument dimensions (cm):

70 (H) x 85 (W) x 58 (D)

Power consumption:

630 W

Power source:

100-120/200-240 V (self-adjusting)

50/60 Hz

Computer

Processor:

Minimum: Intel® Pentium® 4 3.6GHz processor,， 1GB RAM

LCD monitor:

20-inch

Operating system:

Windows® XP

Regulatory

Regulatory:

For Research Use Only. Not for Use in diagnostic procedures